Mary Dasso, Ph.D.

Co-Scientific Director
NIH Oxford-Cambridge Scholars Program

Dr. Mary Dasso is a Senior Investigator in the Division of Intramural Research, National Institute of Child Health and Human Development (NICHD-DIR). Dr. Dasso received her BA in Chemistry from the Clark Honors College at the University of Oregon. She was awarded a Marshall Scholarship to study at the University of Cambridge. After receiving her PhD in Biochemistry, she was awarded a Damon Runyon Postdoctoral Fellowship to work at the University of California, San Diego. She then moved to the NICHD-DIR, where she continues to lead a highly active research group. Dr. Dasso’s studies focus on non-canonical roles of the nuclear transport machinery. Proteins of the nuclear pore complex (nucleoporins) have been implicated in cellular functions beyond nucleocytoplasmic transport, including chromosome organization, gene expression, cell signaling and cell-cycle control. Understanding the activities of individual nucleoporins has been historically difficult because of their multifaceted nature, abundance, and unusual stability. To overcome these issues, she developed human tissue-culture cells that allow conditional depletions of individual nucleoporins, and used this system to define the mechanisms through which individual nucleoporins contribute to nuclear pore structure, nuclear trafficking, gene expression and development. She is currently investigating tissue-specific roles of nucleoporins, with the hope of understanding how disruption of nucleoporin functions causes genetic diseases and neurodegenerative conditions. Beyond her own laboratory, Dr. Dasso has held Intramural NIH leadership positions, including recent service as the NICHD-DIR Acting Scientific Director. She has received numerous awards in recognition of her accomplishments, including a 2020 NIH Director’s Award and a 2021 NICHD Merit Award, as well as selection as a fellow of the American Society for Cell Biology and the American Association for the Advancement of Science.

Source: https://irp.nih.gov/pi/mary-dasso